Endocrine Abstracts

Proliferative inflammatory atrophy and prostatic intraepithelial neoplasia are the first signs of prostate cancer. This inflammatory etiology, together with the infiltration of immune cells, could lead to the binding of the cytokines with cancer cells, forming a population that could initiate tumor growth. [1] Androgens also play an essential role in prostate tumor growth, as is well documented. [2] Androgen deprivation therapy is currently the gold standard for hormone-sensit...

It is well-known that the increase of intraprostatic levels of 5α-dihydrotestosterone is related to the development of prostatic pathologies such as benign prostatic hyperplasia and prostate cancer. So finasteride and dutasteride-based therapies have been used to improve these diseases. These drugs are potent inhibitors of the enzyme 5α-reductase, which is found in the androgen-dependent tissues. This enzyme is responsible for converting testosterone into dihydrotest...